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C&O Canal 100

Knoxville, United States • 25 Apr 2026

C&O Canal 100 - Knoxville, MD

The C&O Canal 100 is a 100-mile ultramarathon held on April 25, 2026, in Knoxville, Maryland, with the event base at Camp Manidokan, 1600 Harpers Ferry Rd. The race is listed as a WSER 2026 qualifier. Registration opens January 1, 2026. The course runs between Antietam and Brunswick, MD, along the C&O Canal towpath and follows the Potomac River with views of the Appalachian mountains.

Course and logistics

The course layout is one approximately 40-mile loop followed by two approximately 30-mile loops.

  • 40-mile loop
  • 30-mile loop
  • 30-mile loop

There will be about seven aid stations placed throughout each loop, some encountered multiple times. Distances between aid stations range from 3 to 6.9 miles. The course is described as having low elevation and smooth terrain and is held in spring, when weather is typically temperate. Volunteers will staff aid stations and support runners along the towpath. Visit the organization's website for the most recent information.

United States Maryland Knoxville

Race information

Website Registration
100 mi
100 Miles
Visit the organization's website for the most recent information.
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